Next-generation Multidimensional NMR Spectrometer Based on Semiconductor Technology

We recently integrated all major functions – RF transmitter, RF receiver, and arbitrary pulse sequencer – of the conventionally bulky NMR spectrometer electronics into a fingertip-sized silicon chip and demonstrated various multidimensional NMR spectroscopy experiments with them, using various bioand organic molecules. We envision that the size and cost economy of such integrated spectrometer chips can open up new exciting vistas in the science and technology of NMR. For example, high-throughput structural analysis of macromolecules can be enabled by operating a large number of the spectrometer chips in parallel inside a high-field superconducting magnet. For another example, online, on-site small-molecule analysis can be performed in a miniaturized, thus portable, platform that combines a spectrometer chip with a low-field compact permanent magnet. In this article, we will discuss the technical background and outlook of this recent synergy between semiconductor chip technology and NMR science.